Top 47 Hericium Erinaceus Lion'S Mane Top 16 Best Answers

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Table of Contents

What is hericium Erinaceus used for?

Hericium erinaceus is a mushroom that grows on trunks of hardwood tress. Hericium erinaceus is taken by mouth for age-related mental decline, Alzheimer’s disease and dementia, depression, anxiety, Parkinson’s disease, multiple sclerosis, and to improve overall mental function and memory.

What are the negative effects of lion’s mane?

Bleeding conditions: Lion’s mane mushroom might slow blood clotting. This might increase the chances of bruising and bleeding in people with bleeding conditions. Surgery: Lion’s mane mushroom might slow blood clotting and reduce blood glucose levels.

What are the benefits of taking lion’s mane?

Research has found that lion’s mane may protect against dementia, reduce mild symptoms of anxiety and depression and help repair nerve damage. It also has strong anti-inflammatory, antioxidant and immune-boosting abilities and been shown to lower the risk of heart disease, cancer, ulcers and diabetes in animals.

Is Lion’s Mane good to take everyday?

Much like other supplements, always consumed alongside a good meal. This also helps to eradicate any feelings of potential nausea. Lion’s mane can be taken up to three times per day, though it is not recommended to exceed this limit. Daily dosages of 250mg to 750mg have also been shown to be effective.

Does lion’s mane work immediately?

Short-term Effects of Lion’s Mane

Depending on your biochemistry, you may feel energizing or anxiolytic effects of lion’s mane after just a couple of days. Many users report decreased anxiety and increased mental clarity after 2-5 days of use. Depending, of course, on the dosage.

How does lion’s mane make you feel?

Lion’s mane is known for reducing symptoms of depression and anxiety, so you can expect your mood to improve if you take the fungus regularly. You’ll also likely feel more clear-headed and focused due to the lion’s mane mushroom’s spiritual benefits and its beneficial effects on cognitive functions.

Can lion’s mane cause anxiety?

No, lion’s mane will not get you high. This mushroom does not contain psychoactive properties and, therefore, can’t alter your perception. However, it can boost your mood and improve your cognition if taken regularly.

Does lion’s mane increase testosterone?

The hormone converts to dihydrotestosterone (DHT, for short) in the body, and exerts its effects on various tissues. Lion’s mane mushrooms may increase the production of testosterone through the beneficial effects it has on the brain (especially on the hypothalamus).

Can lion’s mane cause high blood pressure?

Does lion’s mane mushroom affect blood pressure? Yes, the lion’s mane mushroom can affect blood pressure.

What time of day should you take lion’s mane?

It’s best to take lion’s mane in the morning or early afternoon. That way you’ll reap its energizing benefits throughout the day. Taking lion’s mane later in the day could make you feel restless and unable to fall asleep.

Which Lions Mane is best?

To find the best lion’s mane supplement, you should look for lion’s mane products that contain low levels of starch, and high levels of beta-glucans, as these will be the highest quality products.

Can you take lion’s mane at night?

Lion’s mane works for many modern people as supporting a balance between clarity and rest. This is why many people take their lion’s mane supplements before bed as an excellent adjunct to their lifestyle that will tend to the body, case by case.

Can lion’s mane cause weight gain?

It’s a great source of iron and potassium, making it a great addition to your post-workout meals. Regular consumption of lion’s mane can reduce weight gain, especially during menopause, according to a 2017 animal study. It also has protective effects against chronic inflammation, which is common in obese people.

Can I take lion’s mane on empty stomach?

Yes, it’s safe to take lion’s mane on an empty stomach. However, if you have a sensitive stomach, doing so could cause some digestion issues. To prevent digestion problems, take your lion’s mane supplements with a meal or opt for fortified foods, such as our granola.

Does lion’s mane improve memory?

Lion’s mane seems to promote neurogenesis in the hippocampus, the part of the brain that has a role in learning and memory. An animal study suggests that Hericium erinaceus can also lessen symptoms of brain fog, which could, in turn, improve memory and learning capabilities.

Are all hericium medicinal?

Uses. Hericium species are commonly found and consumed in North America and China. The species is readily cultivated. Hericium is used in the folk medicine of China and Japan, but there is no high-quality clinical research as of 2020 to indicate that it has any medicinal or biological properties.

Are all hericium edible?

There are four or five kinds in North America, but it doesn’t matter which one for the purposes of eating – all four are safe and good to eat. It looks like a white grouping of icicles.

Can I take lion’s mane at night?

So, taking lion’s mane before bed not only supports a healthy night’s sleep. It may also support healthy daytime wakefulness regulated by the circadian rhythm.

Where does hericium Erinaceus grow?

Where to find Lion’s Mane Mushroom in their natural habitat? Lion’s mane mushroom (hericium species) can be found in North America and Canada growing on dead logs in late summer and fall. Other places lions mane mushroom can be found is in the wounds of dying or dead trees. It is typically always found on hardwoods.

Brain Booster? The Magic Power Of Lion’s Mane Mushroom (aka Hericium erinaceus)

Hericium Erinaceus: Health Benefits, Side Effects, Uses, Dose & Precautions

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Most searched keywords: Whether you are looking for Hericium Erinaceus: Health Benefits, Side Effects, Uses, Dose & Precautions Updating Learn more about Hericium Erinaceus health benefits, uses, side effects, effectiveness, safety, precautions, and warningsHericium Erinaceus
Bearded Tooth, Hedgehog Fungus, Lion’s Mane, Monkey Head, Monkey’s Head, Pom Pom, Pompom, Satyr’s Beard, Tree Hedgehog, Yamabushitake.

Bearded Tooth, Hedgehog Fungus, Lion’s Mane, Monkey Head, Monkey’s Head, Pom Pom, Pompom, Satyr’s Beard, Tree Hedgehog, Yamabushitake.

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Most searched keywords: Whether you are looking for 9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects) Updating Lion’s mane mushrooms contain bioactive substances that have beneficial effects on the body, especially the brain, heart and gut. Here are 9 health benefits of lion’s main mushrooms and their extracts.
Table of Contents:

1 Could Protect Against Dementia

2 Helps Relieve Mild Symptoms of Depression and Anxiety

3 May Speed Recovery from Nervous System Injuries

4 Protects Against Ulcers in the Digestive Tract

5 Reduces Heart Disease Risk

6 Helps Manage Diabetes Symptoms

7 May Help Fight Cancer

8 Reduces Inflammation and Oxidative Stress

9 Boosts the Immune System

Safety and Side Effects

The Bottom Line

9 Health Benefits of Lion's Mane Mushroom (Plus Side Effects) — 9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects)

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How Much Lion’s Mane Should I Take Daily

When is the best time to take Lion’s Mane mushroom

Which is the best way to take lion’s mane powder

How Much Lion's Mane Should I Take? | Rritual Superfoods — How Much Lion’s Mane Should I Take? | Rritual Superfoods

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Table of Contents:

Contents

Common names[edit]

Morphology[edit]

Development[edit]

Distribution[edit]

Conservation[edit]

Strains and yield[edit]

Uses[edit]

Ecology[edit]

Cultivation[edit]

Similar species[edit]

Gallery[edit]

LION’S MANE MUSHROOM: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Abdulla MA, Fard AA, Sabaratnam V, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms. 2011;13(1):33-9. View abstract.

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evid Based Complement Alternat Med. 2012;2012:464238. View abstract.

Chang HC, Yang HL, Pan JH, et al. Hericium erinaceus Inhibits TNF-a-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-?B Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells. Oxid Med Cell Longev. 2016;2016:8257238. View abstract.

Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016;16(1):170. View abstract.

Cui F, Gao X, Zhang J, et al. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol. 2016 Jun 4. [Epub ahead of print] View abstract.

Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol. 2013;52:66-71. View abstract.

Hao L, Xie Y, Wu G, et al. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:418023. View abstract.

Hiwatashi K, Kosaka Y, Suzuki N, et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74(7):1447-51. View abstract.

Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015;11(5):3794-9. View abstract.

Kim SP, Kang MY, Choi YH, et al. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct. 2011;2(6):348-56. View abstract.

Kim SP, Kang MY, Kim JH, Nam SH, Friedman M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J Agric Food Chem. 2011;59(18):9861-9. View abstract.

Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012;60(22):5590-6. View abstract.

Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. 2013;61(20):4898-904. View abstract.

Kuo HC, Lu CC, Shen CH, et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med. 2016;14:78. [RETRACTED]. View abstract.

Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. View abstract.

Lee JS, Hong EK. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett. 2010;297(2):144-54. View abstract.

Lee JS, Min KM, Cho JY, Hong EK. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol. 2009;19(9):951-9. View abstract.

Lee KF, Chen JH, Teng CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15(9):15073-89. View abstract.

Lee SR, Jung K, Noh HJ, et al. A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorg Med Chem Lett. 2015;25(24):5712-5. View abstract.

Li G, Yu K, Li F, et al. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. J Ethnopharmacol. 2014;153(2):521-30. View abstract.

Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer’s disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. View abstract.

Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. View abstract.

Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp Ther Med. 2015;9(2):483-487. View abstract.

Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2016;183:54-8. View abstract.

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72. View abstract.

Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. View abstract.

Mori K, Obara Y, Hirota M, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32. View abstract.

Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid ß(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67-72. View abstract.

Nagano M, Shimizu K, Kondo R, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res 2010;31(4):231-7. View abstract.

Phan CW, Lee GS, Hong SL, et al. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. View abstract.

Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion’s mane mushroom). Biomed Res Int. 2014;2014:828149. View abstract.

Rossi P, Cesaroni V, Brandalise F, et al. Dietary supplementation of lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. Int J Med Mushrooms. 2018;20(5):485-494. View abstract.

Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus extract reduces anxiety and depressive behaviors by promoting hippocampal neurogenesis in the adult mouse brain. J Med Food. 2018;21(2):174-180. View abstract.

Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. View abstract.

Samberkar S, Gandhi S, Naidu M, et al. Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study. Int J Med Mushrooms. 2015;17(11):1047-54. View abstract.

Tsai-Teng T, Chin-Chu C, Li-Ya L, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016;23(1):49. View abstract.

Tzeng TT, Chen CC, Chen CC, et al. The cyanthin diterpenoid and sesterterpene constituents of Hericium erinaceus mycelium ameliorate Alzheimer’s disease-related pathologies in APP/PS1 transgenic mice. Int J Mol Sci. 2018;19(2). pii: E598. View abstract.

Wang K, Bao L, Qi Q, et al. Erinacerins C-L, isoindolin-1-ones with a-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod. 2015;78(1):146-54. View abstract.

Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol Macromol. 2015;81:656-61. View abstract.

Wang XL, Xu KP, Long HP, et al. New isoindolinones from the fruiting bodies of Hericium erinaceum. Fitoterapia. 2016;111:58-65. View abstract .

Wong JY, Abdulla MA, Raman J, et al. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. View abstract .

Wong KH, Kanagasabapathy G, Naidu M, David P, Sabaratnam V. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Chin J Integr Med. 2014 Aug 26. View abstract.

Wong KH, Naidu M, David P, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;2011:580752. View abstract.

Xu CP, Liu WW, Liu FX, et al. A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Chin Med J (Engl). 1985;98(6):455-6. View abstract.

Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. 2003;67(6):1292-8. View abstract.

Yi Z, Shao-Long Y, Ai-Hong W, et al. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. 2015;2015:595480. View abstract.

Zan X, Cui F, Li Y, et al. Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. Int J Biol Macromol. 2015;76:242-53. View abstract.

Zhang CC, Yin X, Cao CY, et al. Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. Bioorg Med Chem Lett. 2015;25(22):5078-82. View abstract.

Hericium Erinaceus: Health Benefits, Side Effects, Uses, Dose & Precautions

References

Abdulla MA, Fard AA, Sabaratnam V, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms. 2011;13(1):33-9. View abstract.

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evid Based Complement Alternat Med. 2012;2012:464238. View abstract.

Chang HC, Yang HL, Pan JH, et al. Hericium erinaceus Inhibits TNF-a-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-?B Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells. Oxid Med Cell Longev. 2016;2016:8257238. View abstract.

Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016;16(1):170. View abstract.

Cui F, Gao X, Zhang J, et al. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol. 2016 Jun 4. [Epub ahead of print] View abstract.

Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol. 2013;52:66-71. View abstract.

Hao L, Xie Y, Wu G, et al. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:418023. View abstract.

Hiwatashi K, Kosaka Y, Suzuki N, et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74(7):1447-51. View abstract.

Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015;11(5):3794-9. View abstract.

Kim SP, Kang MY, Choi YH, et al. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct. 2011;2(6):348-56. View abstract.

Kim SP, Kang MY, Kim JH, Nam SH, Friedman M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J Agric Food Chem. 2011;59(18):9861-9. View abstract.

Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012;60(22):5590-6. View abstract.

Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. 2013;61(20):4898-904. View abstract.

Kuo HC, Lu CC, Shen CH, et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med. 2016;14:78. View abstract.

Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. View abstract.

Lee JS, Hong EK. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett. 2010;297(2):144-54. View abstract.

Lee JS, Min KM, Cho JY, Hong EK. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol. 2009;19(9):951-9. View abstract.

Lee KF, Chen JH, Teng CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15(9):15073-89. View abstract.

Lee SR, Jung K, Noh HJ, et al. A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorg Med Chem Lett. 2015;25(24):5712-5. View abstract.

Li G, Yu K, Li F, et al. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. J Ethnopharmacol. 2014;153(2):521-30. View abstract.

Li IC, Chen YL, Lee LY, et al. Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014;70:61-7. View abstract.

Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. View abstract.

Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp Ther Med. 2015;9(2):483-487. View abstract.

Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2016;183:54-8. View abstract.

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72. View abstract.

Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. View abstract.

Mori K, Obara Y, Hirota M, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32. View abstract.

Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid ß(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67-72. View abstract.

Phan CW, Lee GS, Hong SL, et al. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. View abstract.

Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion’s mane mushroom). Biomed Res Int. 2014;2014:828149. View abstract.

Samberkar S, Gandhi S, Naidu M, et al. Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study. Int J Med Mushrooms. 2015;17(11):1047-54. View abstract.

Tsai-Teng T, Chin-Chu C, Li-Ya L, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016;23(1):49. View abstract.

Wang K, Bao L, Qi Q, et al. Erinacerins C-L, isoindolin-1-ones with a-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod. 2015;78(1):146-54. View abstract.

Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol Macromol. 2015;81:656-61. View abstract.

Wang XL, Xu KP, Long HP, et al. New isoindolinones from the fruiting bodies of Hericium erinaceum. Fitoterapia. 2016;111:58-65. View abstract .

Wong JY, Abdulla MA, Raman J, et al. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. View abstract .

Wong KH, Kanagasabapathy G, Naidu M, David P, Sabaratnam V. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Chin J Integr Med. 2014 Aug 26. View abstract.

Wong KH, Naidu M, David P, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;2011:580752. View abstract.

Xu CP, Liu WW, Liu FX, et al. A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Chin Med J (Engl). 1985;98(6):455-6. View abstract.

Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. 2003;67(6):1292-8. View abstract.

Yi Z, Shao-Long Y, Ai-Hong W, et al. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. 2015;2015:595480. View abstract.

Zan X, Cui F, Li Y, et al. Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. Int J Biol Macromol. 2015;76:242-53. View abstract.

Zhang CC, Yin X, Cao CY, et al. Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. Bioorg Med Chem Lett. 2015;25(22):5078-82. View abstract.

LION’S MANE MUSHROOM: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Abdulla MA, Fard AA, Sabaratnam V, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms. 2011;13(1):33-9. View abstract.

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evid Based Complement Alternat Med. 2012;2012:464238. View abstract.

Chang HC, Yang HL, Pan JH, et al. Hericium erinaceus Inhibits TNF-a-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-?B Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells. Oxid Med Cell Longev. 2016;2016:8257238. View abstract.

Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016;16(1):170. View abstract.

Cui F, Gao X, Zhang J, et al. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol. 2016 Jun 4. [Epub ahead of print] View abstract.

Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol. 2013;52:66-71. View abstract.

Hao L, Xie Y, Wu G, et al. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:418023. View abstract.

Hiwatashi K, Kosaka Y, Suzuki N, et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74(7):1447-51. View abstract.

Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015;11(5):3794-9. View abstract.

Kim SP, Kang MY, Choi YH, et al. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct. 2011;2(6):348-56. View abstract.

Kim SP, Kang MY, Kim JH, Nam SH, Friedman M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J Agric Food Chem. 2011;59(18):9861-9. View abstract.

Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012;60(22):5590-6. View abstract.

Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. 2013;61(20):4898-904. View abstract.

Kuo HC, Lu CC, Shen CH, et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med. 2016;14:78. [RETRACTED]. View abstract.

Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. View abstract.

Lee JS, Hong EK. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett. 2010;297(2):144-54. View abstract.

Lee JS, Min KM, Cho JY, Hong EK. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol. 2009;19(9):951-9. View abstract.

Lee KF, Chen JH, Teng CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15(9):15073-89. View abstract.

Lee SR, Jung K, Noh HJ, et al. A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorg Med Chem Lett. 2015;25(24):5712-5. View abstract.

Li G, Yu K, Li F, et al. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. J Ethnopharmacol. 2014;153(2):521-30. View abstract.

Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer’s disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. View abstract.

Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. View abstract.

Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp Ther Med. 2015;9(2):483-487. View abstract.

Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2016;183:54-8. View abstract.

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72. View abstract.

Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. View abstract.

Mori K, Obara Y, Hirota M, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32. View abstract.

Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid ß(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67-72. View abstract.

Nagano M, Shimizu K, Kondo R, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res 2010;31(4):231-7. View abstract.

Phan CW, Lee GS, Hong SL, et al. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. View abstract.

Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion’s mane mushroom). Biomed Res Int. 2014;2014:828149. View abstract.

Rossi P, Cesaroni V, Brandalise F, et al. Dietary supplementation of lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. Int J Med Mushrooms. 2018;20(5):485-494. View abstract.

Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus extract reduces anxiety and depressive behaviors by promoting hippocampal neurogenesis in the adult mouse brain. J Med Food. 2018;21(2):174-180. View abstract.

Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. View abstract.

Samberkar S, Gandhi S, Naidu M, et al. Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study. Int J Med Mushrooms. 2015;17(11):1047-54. View abstract.

Tsai-Teng T, Chin-Chu C, Li-Ya L, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016;23(1):49. View abstract.

Tzeng TT, Chen CC, Chen CC, et al. The cyanthin diterpenoid and sesterterpene constituents of Hericium erinaceus mycelium ameliorate Alzheimer’s disease-related pathologies in APP/PS1 transgenic mice. Int J Mol Sci. 2018;19(2). pii: E598. View abstract.

Wang K, Bao L, Qi Q, et al. Erinacerins C-L, isoindolin-1-ones with a-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod. 2015;78(1):146-54. View abstract.

Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol Macromol. 2015;81:656-61. View abstract.

Wang XL, Xu KP, Long HP, et al. New isoindolinones from the fruiting bodies of Hericium erinaceum. Fitoterapia. 2016;111:58-65. View abstract .

Wong JY, Abdulla MA, Raman J, et al. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. View abstract .

Wong KH, Kanagasabapathy G, Naidu M, David P, Sabaratnam V. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Chin J Integr Med. 2014 Aug 26. View abstract.

Wong KH, Naidu M, David P, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;2011:580752. View abstract.

Xu CP, Liu WW, Liu FX, et al. A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Chin Med J (Engl). 1985;98(6):455-6. View abstract.

Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. 2003;67(6):1292-8. View abstract.

Yi Z, Shao-Long Y, Ai-Hong W, et al. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. 2015;2015:595480. View abstract.

Zan X, Cui F, Li Y, et al. Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. Int J Biol Macromol. 2015;76:242-53. View abstract.

Zhang CC, Yin X, Cao CY, et al. Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. Bioorg Med Chem Lett. 2015;25(22):5078-82. View abstract.

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